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RCT
ACE Report #9092
Ace Report Cover Spine

Single preoperative dose of pregabalin 150mg offers short analgesic efficacy in PLIF cases


Study Type:Therapy
OE Level Evidence:2
Journal Level of Evidence:N/A

A randomized placebo-controlled study of preoperative pregabalin for postoperative analgesia in patients with spinal surgery

J Clin Anesth. 2016 Jun;31:149-53

Contributing Authors: N Fujita M Tobe N Tsukamoto S Saito H Obata

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Synopsis

97 patients scheduled for posterior lumbar interbody fusion were randomized to postoperative analgesia through one of three groups: pregabalin 75mg, pregabalin 150mg, or diazepam 5mg as an active placebo. The purpose of this study was to determine the analgesic efficacy of the two pregabalin doses. Pain scores and patient-controlled morphine consumption were assessed over the first 48 hours postop...

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