Efficacy of zoledronic acid following PLIF in patients with osteoporosis

Study Type:Therapy

OE Level Evidence:2

Journal Level of Evidence:N/A

Effects of zoledronic acid on bone fusion in osteoporotic patients after lumbar fusion

Osteoporos Int. 2016 Apr;27(4):1469-76

Contributing Authors: F Chen Z Dai Y Kang G Lv ET Keller Y Jiang

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Synopsis

79 patients with osteoporosis scheduled for instrumented posterior lumbar interbody fusion due to single-level degenerative spondylolisthesis were randomized to be postoperatively administered either zoledronic acid or saline. The purpose of this study was to compare groups based on fusion status, the incidence of a subsequent vertebral compression fracture, clinical outcome, serum biomarkers of b...