The use of OP-1 (BMP-7) is not recommended for instrumented single-level lumbar fusion
OP-1 Compared with Iliac Crest Autograft in Instrumented Posterolateral Fusion: A Randomized, Multicenter Non-Inferiority TrialJ Bone Joint Surg Am. 2016 Mar 16;98(6):441-8
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119 patients scheduled for instrumented single-level posterolateral lumbar fusion were randomized to a graft source of either osteogenic protein-1 (OP-1; Stryker) or autologous iliac crest bone (ICBG). The purpose of this study was to evaluate if OP-1 was non-inferior to ICBG based on an overall success endpoint which was defined as successful fusion, a relative improvement on the Oswestry Disabil...
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