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RCT
ACE Report #8490
Ace Report Cover General Orthopaedics

Hyaluronic acid more effective versus methylprednisolone in the long term for knee OA


Study Type:Therapy
OE Level Evidence:2
Journal Level of Evidence:N/A

Intra-articular treatment of osteoarthritis of the knee: an arthroscopic and clinical comparison between sodium hyaluronate (500-730 kDa) and methylprednisolone acetate

J Orthopaed Traumatol (2002) 3:89–96

Contributing Authors: L Frizziero IP Ronchetti

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Synopsis

99 patients with knee osteoarthritis (OA) were randomized to treatment with either hyaluronic acid (HA) or methylprednisolone acetate (MP) and followed up for 180 days. The purpose of this study was to determine the clinical efficacy and the structural effects of the two intra-articular injections. MP showed lower pain scores compared to HA initially following injection up to 35 days, although the...

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