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RCT
ACE Report #8014
Ace Report Cover Arthroplasty

TXA effective in reducing blood loss and transfusion in TKA vs. routine hemostasis


Study Type:Therapy
OE Level Evidence:2
Journal Level of Evidence:1

Topical and intravenous tranexamic acid reduce blood loss compared to routine hemostasis in total knee arthroplasty: a multicenter, randomized, controlled trial

Arch Orthop Trauma Surg. 2015 Jul;135(7):1017-25

Contributing Authors: X Aguilera MJ Martínez-Zapata P Hinarejos M Jordán J Leal JC González JC Monllau F Celaya A Rodríguez-Arias JA Fernández X Pelfort LL Puig-Verdie

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Synopsis

150 patients undergoing primary total knee arthroplasty (TKA) were randomized to receive 1 g of topical tranexamic acid (TXA), 2 g of intravenous TXA, or routine hemostasis. The purpose of the study was to determine which TXA administration modality more effectively reduced total blood loss 24 post-surgery and the need for subsequent blood transfusions. Findings indicated that although a significa...

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