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ACE Report #7589
Ace Report Cover Arthroplasty

Topical tranexamic acid and betadine combination effective for reducing blood loss in TKA


Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:1

Bleeding reduction after topical application of tranexamic acid together with Betadine solution in total knee arthroplasty. A randomised controlled study.

Orthop Traumatol Surg Res. 2015 Feb;101(1):83-7.

Contributing Authors: Carvalho LH E Frois Temponi LF Machado Soares MB Gonçalves L Paiva Costa ML Tavares de Souza

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Synopsis

125 patients undergoing total knee arthroplasty were randomized to receive either 1.5g or 3g of topical tranexamic acid (TXA) in 100mL of povidone-iodine solution, or simply the povidone-iodine solution alone into the knee before wound closure. The purpose of this study was to examine the effect of this combination of topical applications on blood loss and infection rate. Secondarily, hemoglobin, ...

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