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ACE Report #7401
Ace Report Cover Arthroplasty

Gabapentin improves in-hospital rehabilitation but not post-discharge outcomes after TKA

Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:N/A

Perioperative gabapentin reduces 24 h opioid consumption and improves in-hospital rehabilitation but not post-discharge outcomes after total knee arthroplasty with peripheral nerve block

Br J Anaesth. 2014 Nov;113(5):855-64.

Contributing Authors: HA Clarke J Katz CJ McCartney P Stratford D Kennedy MG Pagé IT Awad J Gollish J Kay

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179 patients undergoing total knee arthroplasty (TKA) were randomized to receive a four day perioperative regimen of either gabapentin or placebo as an adjunct to celecoxib. The primary intent of this trial was to determine whether gabapentin improves in-hospital rehabilitation and physical function 4 days, 6 weeks, and 3 months after surgery. No significant differences in favour of gabapentin wer...

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