Intravenous, intraarticular irrigation, and drain administration of TXA in TKA
Comparing Efficacy of Three Methods of Tranexamic Acid Administration in Reducing Hemoglobin Drop Following Total Knee ArthroplastyJ Arthroplasty. 2014 Aug;29(8):1521-4
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200 patients scheduled for unilateral total knee arthroplasty (TKA) were randomly allocated to 4 groups to determine if there is a difference in efficacy between different administration methods of TXA. In group 1, 500 mg TXA was administered intravenously. In group 2, the joint was irrigated with 3 g of TXA in 100 cc of saline. In group 3, 1.5 g of TXA was injected through the drain and group 4 d...
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