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Collagenase injections: A non-surgical modality in treating Dupuytren's Disease

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Ace Report Cover
March 2013

Collagenase injections: A non-surgical modality in treating Dupuytren's Disease

Vol: 2| Issue: 2| Number:75| ISSN#: 2564-2537
Study Type:Therapy
OE Level Evidence:2
Journal Level of Evidence:N/A

Injectable collagenase Clostridium histolyticum: A new nonsurgical treatment for Dupuytren's disease

Journal of Hand Surgery American; 2010; 35(A); 2027-2038

Contributing Authors:
D Gilpin S Coleman S Hall A Houston J Karrasch N Jones

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Synopsis

66 patients with contractures, affecting either the metacarpophalangeal (MCP) or proximal interphalangeal (PIP) joints, were randomized to receive Xiaflex (collagenase clostridium histolyticum) or placebo local injection. The results of the 9-month long trial indicated that patients who received Xiaflex displayed significantly greater range of motion and a significantly decreased degree of joint c...

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