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Short-term benefits of tamoxifen in Dupuytren patients with a predisposition to fibrosis
July 2014
Short-term benefits of tamoxifen in Dupuytren patients with a predisposition to fibrosis
Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:1
High-dosage tamoxifen as neoadjuvant treatment in minimally invasive surgery for dupuytren disease in patients with a strong predisposition toward fibrosis: a randomized controlled trial
J Bone Joint Surg Am. 2014 Apr 16;96(8):655-62Synopsis
30 patients suffering from Dupuytren disease, with a predisposition toward fibrosis, were randomized to evaluate the efficacy of tamoxifen against a placebo, following subtotal fasciectomy. Patients were regularly assessed over 2 years to evaluate improvements of total passive extension deficit, and satisfaction as determined by the visual analogue scale (VAS).The evidence presented in this trial ...
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