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Parecoxib reduces pain and local inflammation factors 3 days after TKA
May 2014
Parecoxib reduces pain and local inflammation factors 3 days after TKA
Study Type:Therapy
OE Level Evidence:2
Journal Level of Evidence:N/A
Effect of perioperative parecoxib on postoperative pain and local inflammation factors PGE2 and IL-6 for total knee arthroplasty: a randomized, double-blind, placebo-controlled study
Eur J Orthop Surg Traumatol. 2014 Apr;24(3):395-401. doi: 10.1007/s00590-013-1203-4. Epub 2013 Mar 13.Did you know you're eligible to earn 0.5 CME credits for reading this report? Click Here
Synopsis
100 patients undergoing routine total knee arthroplasty were randomized to receive a parecoxib sodium analgesic regimen or placebo post-surgery, with the primary purpose of evaluating total morphine consumption during the first 24 hours postoperatively. Upon analysis, parecoxib sodium significantly reduced morphine consumption, pain at rest and during movement, and concentration of IL-6 and PGE-2 ...
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