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RCT
ACE Report #552
Ace Report Cover Arthroplasty

Tranexamic Acid Reduces Blood Loss and Blood Transfusion after TKA


Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:N/A

Tranexamic acid reduces blood loss and blood transfusion after TKA: a prospective randomized controlled trial

Clin Orthop Relat Res. 2011 Oct;469(10):2874-80. Epub 2011 Apr 22

Contributing Authors: Keerati Charoencholvanich Pichet Siriwattanasakul

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Synopsis

100 patients with primary osteoarthritis who were scheduled to undergo unilateral cemented total knee arthroplasty were randomized to receive either placebo or intravenous tranexamic acid 10 minutes prior to surgery, 3 hours after surgery, and orally for 5 days after surgery. Patients who received tranexamic acid displayed significantly less blood loss, hemoglobin loss, and required significantly ...

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