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ACE Report #4585
Ace Report Cover General Orthopaedics

Ronacaleret does not significantly reduce time to healing of distal radius fracture

Study Type:Randomized Trial
OE Level Evidence:2
Journal Level of Evidence:N/A

Ronacaleret, a calcium-sensing receptor antagonist, has no significant effect on radial fracture healing time: results of a randomized, double-blinded, placebo-controlled Phase II clinical trial

Bone. 2011 Oct;49(4):845-52. doi: 10.1016/j.bone.2011.06.017. Epub 2011 Jun 30

Contributing Authors: LA Fitzpatrick PL Smith TA McBride MA Fries M Hossain CE Dabrowski DN Gordon

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85 patients were randomized to determine the effect of orally administered ronacaleret, a calcium-sensing receptor antagonist, on distal radius fracture healing. Patients were prescribed either 200mg ronacaleret twice daily, 400mg ronacaleret once daily, or a placebo for 12 weeks. The results indicated neither ronacaleret regimen significantly reduced time to radiographic healing of the fracture, ...

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