ACE Report #4540
Ace Report Cover Arthroplasty

Tranexamic acid is safe and effective in reducing blood loss in TKA

Study Type:Meta analysis
OE Level Evidence:1
Journal Level of Evidence:N/A

Effectiveness and safety of tranexamic acid in reducing blood loss in total knee arthroplasty: a meta-analysis

J Bone Joint Surg Am. 2012 Jul 3;94(13):1153-9. doi: 10.2106/JBJS.K.00873

Contributing Authors: ZG Yang WP Chen LD Wu

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The meta-analysis took results from 15 RCTs (837 patients), published before May 2011, to study the efficacy and safety of Tranexamic acid compared to a placebo in patients undergoing total knee arthroplasty (TKA). The results found that Tranexamic acid significantly reduced blood loss, number of blood transfusion units, and number of patients needing transfusion. It also did not change prothrombi...

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