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Volume:2 Issue:8 Number:21 ISSN#:2563-5476
Author Verified
Meta-analysis
ACE Report #4450
Ace Report Cover Arthroplasty

New oral anticoagulants do not differ significantly in safety and efficacy from enoxaparin


How to Cite

OrthoEvidence. New oral anticoagulants do not differ significantly in safety and efficacy from enoxaparin. ACE Report. 2013;2(8):21. Available from: https://myorthoevidene.com/AceReport/Report/4450

Study Type:Meta-analysis/Systematic Review
OE Level Evidence:1
Journal Level of Evidence:N/A

Dabigatran, rivaroxaban, or apixaban versus enoxaparin for thromboprophylaxis after total hip or knee replacement: systematic review, meta-analysis, and indirect treatment comparisons

BMJ. 2012 Jun 14;344:e3675. doi: 10.1136/bmj.e3675

Contributing Authors: A Gomez-Outes AI Terleira-Fernandez ML Suarez-Gea E Vargas-Castrillon

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Synopsis

A meta-analysis of 16 randomized trials (38747 patients) was conducted to investigate the effects of new oral anticoagulants (rivaroxaban, dabigatran, and apixaban), compared with standard enoxaparin, for prophylaxis against venous thromboembolism after total hip or knee replacement surgery. After investigating relative risks of symptomatic venous thromboembolism, clinically relevant bleeding, and...

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