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5-hydroxytryptamine receptor inhibitor is safe and effective for treatment of lumbar disc
July 2014
5-hydroxytryptamine receptor inhibitor is safe and effective for treatment of lumbar disc
Study Type:Therapy
OE Level Evidence:2
Journal Level of Evidence:N/A
New treatment of lumbar disc herniation involving 5-hydroxytryptamine2A receptor inhibitor: a randomized controlled trial
J Neurosurg Spine. 2005 Apr;2(4):441-6Did you know you're eligible to earn 0.5 CME credits for reading this report? Click Here
Synopsis
Forty patients with sciatica due to L4-5 or L5-S1 disc herniation were randomized to receive treatment with the 5-HT2A inhibitor or nonsteroidal anti-inflammatory drugs (NSAIDs) for 2 weeks. After 2 weeks, both groups demonstrated significant reductions in low-back and leg pain as well as leg numbness, but there was no significant difference between the two groups for any of these outcomes. Over 1...
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