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Meta-analysis
ACE Report #4208
Ace Report Cover General Orthopaedics

Novel oral anticoagulants are similar to conventional treatment for venous thromboembolism


Study Type:Meta-analysis/Systematic Review
OE Level Evidence:1
Journal Level of Evidence:N/A

Efficacy and safety of novel oral anticoagulants for treatment of acute venous thromboembolism: Direct and adjusted indirect meta-analysis of randomised controlled trials

BMJ. 2012 Nov 13;345:e7498. doi: 10.1136/bmj.e7498

Contributing Authors: BD Fox SR Kahn D Langleben MJ Eisenberg A Shimony

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Synopsis

This meta-analysis and systematic review included 9 studies comparing novel oral anticoagulants (with or without initial treatment with heparin) to vitamin K antagonists (always with inital treatment with heparin) in patients with acute venous thromboembolism. From the 9 studies, 16 701 patients were assessed with regards to the efficacy of the drugs and 16 611 were evaluated on safety. Results in...

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