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ACE Report #4063
Ace Report Cover Trauma

OTA: Indomethacin is no better than placebo for preventing heterotopic ossification

Study Type:Randomized Trial
OE Level Evidence:N/A
Journal Level of Evidence:N/A

Incidence of Posterior Wall Nonunion and Efficacy of Indomethacin Prophylaxis for Heterotopic Ossification After Operative Fixation of Acetabular Fractures: A Randomized Controlled Trial

Contributing Authors: Charles J Jordan Rafael Serrano-Riera H Claude Sagi

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This ACE Report is a summary of a conference presentation or abstract. The information provided has limited the ability to provide an accurate assessment of the risk of bias or the overall quality. Please interpret the results with caution as trials may be in progress and select results may have been presented.


98 patients with an acetabular fracture were included in a study to examine the effects of indomethacin on the prevention of heterotopic ossification (HO). Patients underwent open reduction and internal fixation through a Kocher-Langenbeck approach. They were then randomized to receive placebo for 6 weeks (group 1), 3 days of indomethacin followed by placebo for a total of 6 weeks (group 2), 1 wee...

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