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Meta-analysis
ACE Report #2957
Ace Report Cover Metabolic Disorders

Cochrane Overview: Biologics more effective than placebo in treating rheumatoid arthritis


Study Type:Meta analysis
OE Level Evidence:1
Journal Level of Evidence:N/A

A network meta-analysis of randomized controlled trials of biologics for rheumatoid arthritis: A Cochrane overview

CMAJ. 2009 Nov 24;181(11):787-96. Epub 2009 Nov 2.

Contributing Authors: JA Singh R Christensen GA Wells ME Suarez-Almazor R Buchbinder MA Lopez-Olivo ET Ghogomu P Tugwell

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Synopsis

This network meta-analysis identified 6 Cochrane Collaboration systematic reviews, comprised in total of 31 studies. These reviews examined the safety and benefits of 6 biologics in patients with rheumatoid arthritis (abatacept, adalimumab, anakinra, etanercept, infliximab and rituximab). The primary outcomes of this study were safety (number of withdrawals related to adverse effects) and benefit ...

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