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Intramedullary Tranexamic Acid to Reduce Blood Loss in Proximal Femoral Nail Antirotation Surgery
November 2025
Intramedullary Tranexamic Acid to Reduce Blood Loss in Proximal Femoral Nail Antirotation Surgery
Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:1
Intramedullary administration of tranexamic acid reduces bleeding in proximal femoral nail antirotation surgery for intertrochanteric fractures in elderly individuals: A randomized controlled trial.
Chin J Traumatol . 2025 May;28(3):201-207.Synopsis
One hundred sixty-five elderly patients with intertrochanteric fractures were randomized to receive intramedullary TXA perfusion (n=83) or intramedullary saline alone (n=82 randomized) during proximal femoral nail antirotation (PFNA) surgery. The primary outcomes were total peri-operative blood loss and post-operative concentrated red blood cell (CRBC) transfusion rate. Secondary outcomes included...
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