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Intrathecal Sufentanil with Bupivacaine Improves Postoperative Analgesia in Elderly Fracture Surgery
November 2025
Intrathecal Sufentanil with Bupivacaine Improves Postoperative Analgesia in Elderly Fracture Surgery
Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:1
Effects of Intrathecal Sufentanil at Different Doses on Postoperative Pain Relief and Opioid Consumption in Elderly Patients Undergoing Lower Limb Orthopedic Surgery: A Randomized Controlled Trial.
J Pain Res . 2025 May 15:18:2439-2451.Synopsis
Two hundred thirty-one patients with lower-limb fractures were randomized to bupivacaine alone (B; n=78), bupivacaine+5 µg sufentanil (BS1; n=85), or bupivacaine+10 µg sufentanil (BS2; n=84). The primary outcomes were postoperative NRS pain scores and rescue analgesic use across postoperative days (POD) 1–3. Secondary outcomes included block characteristics and adverse events. Outcomes were assess...
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