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Benzoyl Peroxide vs Standard Prep for Reducing Cutibacterium acnes in THA
November 2025
Benzoyl Peroxide vs Standard Prep for Reducing Cutibacterium acnes in THA
Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:1
The Frank Stinchfield Award: Preoperative Surgical Skin Cleansing Protocols Are Not Effective at Decreasing the Burden of Cutibacterium acnes Before Total Hip Arthroplasty.
J Arthroplasty . 2025 Aug;40(8S1):S3-S8.Synopsis
Three hundred thirty-seven patients with primary hip or knee osteoarthritis undergoing elective lower extremity arthroplasty with hip skin biopsies were randomized to receive either standard preoperative skin preparation with 4% chlorhexidine gluconate alone (n = 173) or the same standard preparation plus four preoperative applications of 5% benzoyl peroxide gel over 48 hours and one additional ap...
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