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IV Lidocaine After Posterior Spinal Instrumentation And Fusion (PSIF): No Opioid-Sparing Effect
November 2025
IV Lidocaine After Posterior Spinal Instrumentation And Fusion (PSIF): No Opioid-Sparing Effect
Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:1
Perioperative Intravenous Lidocaine Infusion Therapy as an Adjunct to Multimodal Analgesia for Adolescent Idiopathic Scoliosis Surgical Correction: A Double-Blind Randomized Controlled Trial.
Paediatr Anaesth . 2025 Jul;35(7):552-561.Synopsis
Fourty-eight adolescents with idiopathic scoliosis were randomized to receive perioperative IV lidocaine (n = 24) or saline placebo (n = 24) as an adjunct to standardized multimodal analgesia that included protocolized morphine titration, acetaminophen, ketorolac, and clonidine during . The primary outcome was cumulative 48-hour morphine utilization (mg/kg). Secondary outcomes included morphine us...
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