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Adverse Events After Adjuvant Radiotherapy for Dupuytren’s Disease: Findings from the DEPART

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Ace Report Cover
October 2025

Adverse Events After Adjuvant Radiotherapy for Dupuytren’s Disease: Findings from the DEPART

Vol: 307| Issue: 10| Number:66| ISSN#: 2564-2537
Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:1

Adverse events after adjuvant radiation therapy for Dupuytren's disease in the DEPART randomized trial.

J Hand Surg Eur Vol . 2025 Jul;50(7):891-897.

Contributing Authors:
T Burgess E Wegener B McClelland D Hunter-Smith PMN Werker J Martin

Synopsis

Sixty patients with Dupuytren’s disease were randomized to receive adjuvant radiotherapy (n=28) or observation (n=30) after limited fasciectomy, percutaneous needle fasciotomy, or collagenase injection. The primary outcome of interest was adverse events (AEs) graded by CTCAE. Secondary outcomes of interest included AE prevalence over time, severity distribution, persistence beyond 6–12 months, wou...

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