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Early Hyperbaric Oxygen Therapy Reduces Muscle Injury and Inflammation After Total Knee Arthroplasty

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Ace Report Cover
October 2025

Early Hyperbaric Oxygen Therapy Reduces Muscle Injury and Inflammation After Total Knee Arthroplasty

Vol: 307| Issue: 10| Number:102| ISSN#: 2564-2537
Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:1

Effect of hyperbaric oxygen therapy on postoperative muscle damage and inflammation following total knee arthroplasty: a randomized controlled trial.

Sci Rep. 2025 Jul 1;15:22039.

Contributing Authors:
R Zhang H Guo S Tang J Zuo X Shi

Synopsis

Eighty patients with primary knee osteoarthritis scheduled for unilateral TKA were randomized to receive hyperbaric oxygen therapy (HBOT) added to standard care (n=40) or normobaric oxygen therapy (n=40). The primary outcome was serum muscle-injury biomarkers (CK, Mb, LDH, GOT). Secondary outcomes included IL-6, CRP, VAS pain (rest/motion), knee ROM, quadriceps strength, swelling ratio, and HSS sc...

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