
Regional vs General Anaesthesia and 12-Month Cognitive Outcomes After Hip-Fracture Surgery

Regional vs General Anaesthesia and 12-Month Cognitive Outcomes After Hip-Fracture Surgery
Incidence of 12-month postoperative cognitive decline following regional vs. general anaesthesia in older patients undergoing hip fracture surgery: follow-up of the RAGA trial.
Anaesthesia . 2025 Jul;80(7):771-780.Synopsis
Nine-hundred and fifty patients with hip fracture were randomised to general anaesthesia (n=474) or regional anaesthesia without sedation (n=476); the 12-month cognitive follow-up analysis included two-hundred and ninety-three patients (general n=139; regional n=154). The primary outcome was 12-month postoperative cognitive decline (MMSE-based Z-score approach versus population controls). Secondar...
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