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Pre-operative Low-Dose Dexmedetomidine Reduces Postoperative Delirium After Hip-Fracture Surgery
October 2025
Pre-operative Low-Dose Dexmedetomidine Reduces Postoperative Delirium After Hip-Fracture Surgery
Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:1
Preoperative low-dose dexmedetomidine reduces postoperative delirium in elderly patients with hip fracture under spinal anesthesia: A randomized, double blind, controlled clinical study.
J Clin Anesth . 2025 Jul:105:111897.Synopsis
Two hundred thirty-three patients with hip fracture were randomized to receive dexmedetomidine 0.1 µg/kg/h from 8 pm (pre-op night) to 8 am (day of surgery) (n=116) or identical-appearing saline (n=117). The primary outcome was POD incidence (3D-CAM) from postoperative day (POD) 1–7 or discharge. Secondary outcomes included preoperative sleep quality (LSEQ, ISI), delirium days, pain (NRS), C-react...
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