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Initial Surgery vs Corticosteroid Injection for Carpal Tunnel Syndrome
October 2025
Initial Surgery vs Corticosteroid Injection for Carpal Tunnel Syndrome
Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:1
Surgery versus corticosteroid injection for carpal tunnel syndrome (DISTRICTS): an open-label, multicentre, randomised controlled trial.
Lancet . 2025 Jun 14;405(10495):2153-2163.Synopsis
Nine hundred fourty one patients with carpal tunnel syndrome (CTS) were randomized to receive initial surgical decompression (n=470) or initial corticosteroid injection (n=471); further interventions were allowed in both arms as needed. The primary outcome was recovery at 18 months (CTS-6 <8). Secondary outcomes included time to recovery, serial CTS-6, upper-limb function (QuickDASH), palmar pain ...
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