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Repeat Oral Dexamethasone After Knee Replacement Fails to Reduce Pain Relapse
October 2025
Repeat Oral Dexamethasone After Knee Replacement Fails to Reduce Pain Relapse
Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:1
Repeat-dose dexamethasone to prevent pain relapse after total knee arthroplasty in high-pain-response patients: A randomised, double-blind, placebo-controlled superiority trial.
Eur J Anaesthesiol . 2025 Jul 1;42(7):599-608.Synopsis
One hundred ten patients with high-pain-response after primary TKA were randomized to receive oral dexamethasone 24 mg on postoperative day 1 (n=55) or placebo (n=55). The primary outcome was the proportion with moderate–to–severe walking pain (VAS>30) at 48 h. Secondary outcomes included pain over days 2–3 and 2–7 (walking, rest, night), rescue opioid use (morphine-milligram equivalents), sleep q...
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