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Condoliase Improves Quality of Life in Lumbar Disc Herniation
September 2025
Condoliase Improves Quality of Life in Lumbar Disc Herniation
Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:1
Impact of Condoliase on Health-related Quality of Life in Participants With Radicular Leg Pain Associated With Lumbar Disk Herniation: Results From a United States Phase 3 Clinical Trial.
Spine (Phila Pa 1976) . 2025 Jun 15;50(12):796-803.Did you know you're eligible to earn 0.5 CME credits for reading this report? Click Here
Synopsis
Three hundred forty-one randomized patients with Lumbar Disk Herniation (LDH) -associated unilateral radicular leg pain were analyzed (modified ITT): condoliase (n=169) vs sham (n=172). The primary outcomes for this exploratory report were HRQoL changes (EQ-5D-5L domains and EQ-VAS) at weeks 13 and 52. Secondary outcomes included SF-36 PCS/MCS, PGIC and CGIC responder proportions, and WPAI domains...
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