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TIVA Lowers Postoperative IL-6 vs Sevoflurane in Lumbar Microdiscectomy
October 2025
TIVA Lowers Postoperative IL-6 vs Sevoflurane in Lumbar Microdiscectomy
Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:1
Comparison of inhalation and total intravenous anesthesia on inflammatory markers in microdiscectomy: a double-blind study.
BMC Anesthesiol . 2025 May 10;25(1):238.Synopsis
Forty patients with symptomatic lumbar disc herniation scheduled for microdiscectomy were randomized to receive propofol-based TIVA (n=20) or sevoflurane anesthesia (n=20). The primary outcome of interest was serum IL-6 at 24 hours post-op. Secondary outcomes of interest included C-reactive protein (CRP), procalcitonin (PCT), neutrophil-to-lymphocyte ratio (NLR) levels; perioperative variables (e....
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