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Perioperative duloxetine for postoperative outcomes in Patients With Depression
February 2025
Perioperative duloxetine for postoperative outcomes in Patients With Depression
Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:1
Perioperative duloxetine improves postoperative outcomes after anterior talofibular ligament repair for chronic lateral ankle instability for patients with depression: A prospective randomized clinical trial.
Orthop Traumatol Surg Res . 2024 Nov;110(7):103837.Did you know you're eligible to earn 0.5 CME credits for reading this report? Click Here
Synopsis
One hundred twenty patients with chronic lateral ankle instability and preoperative depression were randomized to receive perioperative duloxetine (n=60) or placebo (n=60) starting one day before ATFL repair and continuing for six weeks postoperatively. The primary outcome was postoperative pain intensity and opioid consumption. Secondary outcomes included time to first rescue analgesic, patient s...
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