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Efficacy and Safety of Zoledronic Acid in the Treatment of Osteoporosis by BMD and Bone Turn Over
February 2025
Efficacy and Safety of Zoledronic Acid in the Treatment of Osteoporosis by BMD and Bone Turn Over
Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:1
Efficacy and safety of zoledronic acid in the treatment of osteoporosis: A meta-analysis of randomized controlled trials.
Heliyon . 2024 Jun 29;10(13):e33871.Did you know you're eligible to earn 0.5 CME credits for reading this report? Click Here
Synopsis
This meta-analysis included 22 randomized controlled trials with a total of 11,852 patients diagnosed with osteoporosis, comparing zoledronic acid treatment to placebo. Pooled outcomes of interest included changes in BMD (lumbar spine, femoral neck, and trochanter), bone turnover markers (CTX, BSAP, and P1NP), serum sclerostin levels, Visual Analogue Scale (VAS) scores, Oswestry Disability Index (...
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