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Gabapentinoids for the Treatment of Acute Postoperative Pain Following Lumbar Spine Fixation Surgery
June 2025
Gabapentinoids for the Treatment of Acute Postoperative Pain Following Lumbar Spine Fixation Surgery
Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:1
The Preoperative Use of Gabapentinoids for the Treatment of Acute Postoperative Pain Following Lumbar Spine Fixation Surgery.
World Neurosurg . 2023 Oct:178:e57-e64.Did you know you're eligible to earn 0.5 CME credits for reading this report? Click Here
Synopsis
A total of 252 patients undergoing lumbar spine fixation for spinal stenosis were randomized to receive either placebo (n=28) or gabapentinoids: pregabalin (75 mg or 150 mg, single or 3-day dosing) or gabapentin (300 mg or 600 mg, single or 3-day dosing). The primary outcome was postoperative pain measured via the visual analog scale (VAS) at 1, 6, 12, and 24 hours. Secondary outcomes included com...
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