Efficacy and Safety of Tranexamic Acid in Hip Fracture Surgery

How to Cite

OrthoEvidence. Efficacy and Safety of Tranexamic Acid in Hip Fracture Surgery. ACE Report. 2022;213(1):2. Available from: https://myorthoevidence.com/AceReport/Report/14422

Study Type:Therapy

OE Level Evidence:1

Journal Level of Evidence:1

Efficacy and safety of tranexamic acid in hip fracture surgery. How does dosage affect outcomes: A meta-analysis of randomized controlled trials

Injury. 2022 Feb;53(2): 294-300.

Contributing Authors:
P Masouros G Antoniou VS Nikolaou

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Synopsis

A meta-analysis of 10 randomized controlled trials (n=1123) undergoing hip fracture surgery with patients randomized to receive perioperative intravenous TXA (n=557) or a control group (n=566) was performed. The primary outcome of interest was total blood loss. Secondary outcomes of interest included transfusion rates and incidence of thromboembolic events. The TXA group demonstrated significantly...