Ramelteon Ineffective in Preventing Post-Op Delirium in Patients Undergoing Joint Replacement

How to Cite

OrthoEvidence. Ramelteon Ineffective in Preventing Post-Op Delirium in Patients Undergoing Joint Replacement. ACE Report. 2021;10(3):2. Available from: https://myorthoevidence.com/AceReport/Report/13120

Study Type:Therapy

OE Level Evidence:1

Journal Level of Evidence:1

Effects of Ramelteon on the Prevention of Postoperative Delirium in Older Patients Undergoing Orthopedic Surgery: The RECOVER Randomized Controlled Trial

Am J Geriatr Psychiatry. 2021 Jan;29(1):90-100.

Contributing Authors: ES Oh JM Leoutsakos PB Rosenberg AM Pletnikova HS Khanuja RS Sterling JK Oni FE Sieber NS Fedarko N Akhlaghi KJ Neufeld

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Synopsis

Eighty patients scheduled for a hip or knee replacement surgery were randomized to receive oral ramelteon (n=41) or placebo (n=39) for the prevention of post-operative delirium. The primary outcome of interest was the incidence of delirium during post-operative day 0 and post-operative day 1-2, as measured by the Aldrete score. Secondary outcomes included the Delirium Rating Scale Revised 98 (DRS-...