Polypill/Aspirin Combination Reduces Cardiovascular Events in Participants with Increased CV Risk

How to Cite

OrthoEvidence. Polypill/Aspirin Combination Reduces Cardiovascular Events in Participants with Increased CV Risk. ACE Report. 2020;9(11):34. Available from: https://myorthoevidene.com/AceReport/Report/12645

Study Type:Therapy

OE Level Evidence:1

Journal Level of Evidence:1

Polypill with or without Aspirin in Persons without Cardiovascular Disease

N Engl J Med. 2020 Nov 13.

Contributing Authors: S Yusuf P Joseph A Dans K Teo D Xavier P Lopez-Jaramillo K Yusoff A Santoso H Gamra S Talukder C Christou P Girish K Yeates F Xavier G Dagenais C Rocha T McCready J Tyrwhitt J Bosch P Pais TIPS-3 Investigators

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Synopsis

Five thousand, seven hundred and thirteen patients with elevated cardiovascular risk were randomized to receive a polypill (containing lipid and blood pressuring lowering agents), aspirin, polypill and aspirin, or placebo for the prevention of cardiovascular events. The primary outcome of interest for the polypill and polypill plus aspirin groups was a composite of death from major cardiovascular ...