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Volume:28 Issue:10 Number:1 ISSN#:2563-5476
ACE Report #12443
Ace Report Cover Osteoarthritis

Long-Term Maintenance of Clodronate Effective in Reducing Pain and Improving Function in Knee OA

Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:1

Intramuscular Clodronate in Long-Term Treatment of Symptomatic Knee Osteoarthritis: A Randomized Controlled Study.

Drugs in R&D.2020 Mar;20(1):39-45

Contributing Authors: B Frediani C Toscano P Falsetti A Nicosia S Pierguidi A Migliore E Conticini S Giannotti L Cantarini

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Seventy-four patients with chronic knee pain from knee osteoarthritis, who received intramuscular clodronate 200 mg/day for 15 days, were randomized into receiving clodronate once/week for the next 11.5 months or once/week for the next 2.5 months. The primary outcome of interest was pain on a Visual Analogue Scale (VAS). Secondary outcomes of interest included the Western Ontario and McMaster Univ...

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