Preemptive Analgesia in Lumbar Spine Surgery Improves Pain and Analgesic Consumption Post-Operation

Study Type:Therapy

OE Level Evidence:1

Journal Level of Evidence:1

Preemptive analgesia with a single low dose of intrathecal morphine in multilevel posterior lumbar interbody fusion surgery: a double-blind, randomized, controlled trial.

Spine J. 2020 Jul;20(7):989-997.

Contributing Authors: Y Wang X Guo Z Guo M Xu

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Synopsis

Ninety-two patients scheduled with an elective multilevel lumbar laminectomy (L3−S1) with fusion were randomized into either receiving 0.2 mg of preoperative intrathecal morphine (ITM) or a control of saline solution. The primary outcome measured was post-operative pain at rest and during movement through a Visual Analogue Scale (VAS) at at 1, 3, 6, 12, 24, 48, and 72 hours after operation. Second...