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RCT
ACE Report #12268
Ace Report Cover General Orthopaedics

Rivaroxaban Superior to Enoxaparin in Non-Major Orthopaedic Surgery for Prevention of Major VTE


Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:1

Rivaroxaban or Enoxaparin in Nonmajor Orthopedic Surgery

N Engl J Med. 2020 May 14;382(20):1916-1925.

Contributing Authors: CM Samama S Laporte N Rosencher P Girard J Llau P Mouret W Fisher D Duverger B Deygas E Presles M Cucherat P Mismetti J Martínez-Martín PRONOMOS Investigators

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Synopsis

Three thousand six hundred and four patients scheduled for a non-major lower limb surgery were randomized to receive oral rivaroxaban or subcutaneous enoxaparin for the prevention of major venous thromboembolic events. The primary outcome of interest was major venous thromboembolism, which was a composite of the incidence of symptomatic distal or proximal deep vein thrombosis, pulmonary embolism a...

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