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Volume:9 Issue:8 Number:3 ISSN#:2563-5476
RCT
ACE Report #12216
Ace Report Cover Cannabis

CBD 600mg Normalizes Neuroendocrine and Anxiety Responses to Stress in Patients at Risk of Psychosis


How to Cite

OrthoEvidence. CBD 600mg Normalizes Neuroendocrine and Anxiety Responses to Stress in Patients at Risk of Psychosis. ACE Report. 2020;9(8):3. Available from: https://myorthoevidence.com/AceReport/Report/12216

Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:N/A

Effects of short-term cannabidiol treatment on response to social stress in subjects at clinical high risk of developing psychosis

Psychopharmacology. 2020;237:1121-1130

Contributing Authors: E Appiah-Kusi N Petros R Wilson M Colizzi MG Bossong L Valmaggia V Mondelli P McGuire S Bhattacharyya

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Synopsis

Thirty-two participants at clinical high risk (CHR) for psychosis were randomized to receive either cannabidiol (CBD) 600 mg/day (CHR-CBD) or placebo (CHR-P) for one week. The CHR participants and 25 healthy controls (HC) then performed a psychosocial stress task. The primary outcome was the neuroendocrine response to stress measured by serum cortisol levels. Other outcomes of interest included su...

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