OTA 2019: Time to irrigation does not independently increase the risk of infection in open fractures

Study Type:Randomized Trial

OE Level Evidence:N/A

Journal Level of Evidence:N/A

The Effect of Time to Irrigation on the Rate of Reoperation in Open Fractures: A Propensity Score-Based Analysis of the Fluid Lavage of Open Wounds (FLOW) Study

Contributing Authors: H Johal D Axelrod S Sprague B Petrisor Sofia Bozovsky M Bhandari

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Synopsis

Infection is of great concern in open fractures. Traditionally, time to irrigation and debridement has been thought to be important, and six hours has been cited as an ideal time target. However, this is based on basic science studies with limited clinical correlation. In this study, the authors performed a secondary analysis of the Fluid Lavage of Open Wounds (FLOW) Trial data. Patients were matc...