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ACE Report #11839
Ace Report Cover General Orthopaedics

COA/ICORS2019: NSAID use >4wks, especially indomethacin, associated with non-union in bone fractures

Study Type:Meta analysis
OE Level Evidence:N/A
Journal Level of Evidence:N/A

The Effect of NSAIDs on Post-Fracture Bone Healing; A Meta-Analysis of Randomized Controlled Trials

Contributing Authors: H Al Farii L Farahdel A Salimi

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This ACE Report is a summary of a conference presentation or abstract. The information provided has limited the ability to provide an accurate assessment of the risk of bias or the overall quality. Please interpret the results with caution as trials may be in progress and select results may have been presented.


6 RCTs (609 patients) were included in this meta-analysis which examined the risk of nonunion after fracture in patients taking non-steroidal anti-inflammatory drugs (NSAIDs). The primary outcome of interest was nonunion, and the relative risk based on duration of use and type of NSAID was analyzed via a regression analysis. The results revealed that NSAID use longer than 4 weeks resulted in a sig...

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