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Multi-dose oral TXA in total knee arthroplasty reduces blood loss with no increase in complication
June 2019
Multi-dose oral TXA in total knee arthroplasty reduces blood loss with no increase in complication
Study Type:Randomized Trial
OE Level Evidence:1
Journal Level of Evidence:1
The efficacy and safety of multiple doses of oral tranexamic acid on blood loss, inflammatory and fibrinolysis response following total knee arthroplasty: A randomized controlled trial
Int J Surg. 2019 May;65:45-51.Did you know you're eligible to earn 0.5 CME credits for reading this report? Click Here
Synopsis
151 patients scheduled for a primary unilateral TKA for osteoarthritis or rheumatoid arthritis were randomized to receive a single 2g dose of oral TXA (2 hrs pre-operation), two doses of oral TXA (2 hrs pre-op, 4 hrs post-op) or multiple doses of oral TXA (2 hrs pre-op, 4, 10 16 hrs post-op). The primary outcome of interest was total blood loss. Results revealed significantly lower amounts of tota...
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