
Multi-dose oral TXA in total knee arthroplasty reduces blood loss with no increase in complication

Multi-dose oral TXA in total knee arthroplasty reduces blood loss with no increase in complication
The efficacy and safety of multiple doses of oral tranexamic acid on blood loss, inflammatory and fibrinolysis response following total knee arthroplasty: A randomized controlled trial
Int J Surg. 2019 May;65:45-51.Did you know you're eligible to earn 0.5 CME credits for reading this report? Click Here
Synopsis
151 patients scheduled for a primary unilateral TKA for osteoarthritis or rheumatoid arthritis were randomized to receive a single 2g dose of oral TXA (2 hrs pre-operation), two doses of oral TXA (2 hrs pre-op, 4 hrs post-op) or multiple doses of oral TXA (2 hrs pre-op, 4, 10 16 hrs post-op). The primary outcome of interest was total blood loss. Results revealed significantly lower amounts of tota...
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