ACE Report #11379
Ace Report Cover Trauma

AAOS2019: Similar efficacy and safety of LMWH 30mg BID and aspirin 81mg BID for VTE prophylaxis

Study Type:Randomized Trial
OE Level Evidence:N/A
Journal Level of Evidence:N/A

A Different Approach to Preventing Thrombosis (ADAPT): A Randomized Trial Comparing Bleeding Events after Orthopaedic Trauma with Aspirin to Low Molecular Weight Heparin Prophylaxis

Contributing Authors: G Slobogean RV O'Toole T Manson NN O'Hara B Haac R van Besien D Stein H Johal P Berger B Reahl D Marinos D Mascarenhas D Connelly T Scalea Y Degani

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This ACE Report is a summary of a conference presentation or abstract. The information provided has limited the ability to provide an accurate assessment of the risk of bias or the overall quality. Please interpret the results with caution as trials may be in progress and select results may have been presented.


329 patients with an operative extremity fracture, or pelvic and/or acetabular fracture and required thromboprophylaxis were randomized to either low molecular weight heparin 30mg twice daily or aspirin 81mg twice daily for 90 days. Patients were followed up for bleeding events and venous thromboembolic complications. Results demonstrated no significant differences between groups in rates of eithe...

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