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ACE Report #11001
Ace Report Cover Metabolic Disorders

Significant reduction in 6-year fragility fracture risk with zoledronate vs placebo for osteopenia


Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:N/A

Fracture Prevention with Zoledronate in Older Women with Osteopenia

N Engl J Med. 2018 Dec 20;379(25):2407-2416. doi: 10.1056/NEJMoa1808082

Contributing Authors: IR Reid S Wong MJ Bolland GD Gamble B Mihov AM Horne A Stewart E Garratt KR Wiessing S Bastin

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Synopsis

2000 postmenopausal women with osteopenia were randomized to treatment with infusion of either zoledronate 5mg or placebo every 18 months for 6 years. Participants were assessed for incidence of fractures, prespecified adverse events including mortality, vascular events, cancer, and osteonecrosis of the jaw, and bone mineral density after 6 years. Results demonstrated significantly lower incidence...

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