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Significant reduction in 6-year fragility fracture risk with zoledronate vs placebo for osteopenia
April 2019
Significant reduction in 6-year fragility fracture risk with zoledronate vs placebo for osteopenia
Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:N/A
Fracture Prevention with Zoledronate in Older Women with Osteopenia
N Engl J Med. 2018 Dec 20;379(25):2407-2416. doi: 10.1056/NEJMoa1808082Did you know you're eligible to earn 0.5 CME credits for reading this report? Click Here
Synopsis
2000 postmenopausal women with osteopenia were randomized to treatment with infusion of either zoledronate 5mg or placebo every 18 months for 6 years. Participants were assessed for incidence of fractures, prespecified adverse events including mortality, vascular events, cancer, and osteonecrosis of the jaw, and bone mineral density after 6 years. Results demonstrated significantly lower incidence...
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