ACE Report #10870
Ace Report Cover Cannabis

Titrated THC and CBD does not significantly improve spasticity compared to placebo over 4 weeks

Study Type:Therapy
OE Level Evidence:2
Journal Level of Evidence:N/A

Sativex and clinical-neurophysiological measures of spasticity in progressive multiple sclerosis

J Neurol. 2015 Nov;262(11):2520-7

Contributing Authors: E Houdayer A Nuara L Straffi G Comi P Rossi LN Leocani I Schiavetti U Del Carro S Amadio V Martinelli C Vila MP Sormani

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34 patients with progressive multiple sclerosis were treated with titrated doses of Sativex (9-delta-tetrahydrocannabinol and cannabidiol oromucosal spray) or placebo in a randomly assigned order for 4 weeks each. The purpose of the study was to determine if of 9-delta-tetrahydrocannabinol and cannabidiol treatment significantly improves neurophysiological and clinical measures of spasticity, pain...

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