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Volume:6 Issue:10 Number:73 ISSN#:2563-5476
ACE Report #10641
Ace Report Cover Trauma

OTA2018: Equivalence not demonstrated, higher union with ICBG vs. rhBMP-2 for open tibial fracture

Study Type:Randomized Trial
OE Level Evidence:N/A
Journal Level of Evidence:N/A

A Randomized Controlled Trial Comparing rhBMP-2 Versus Autograft for the Treatment of Tibia Fractures With Critical Size Defects

Contributing Authors: Paul Tornetta W Obremskey L Cannada L Reider J Luly E MacKenzie

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This ACE Report is a summary of a conference presentation or abstract. The information provided has limited the ability to provide an accurate assessment of the risk of bias or the overall quality. Please interpret the results with caution as trials may be in progress and select results may have been presented.


23 patients with an open midshaft tibial fracture fixed with an intramedullary nail were randomized to grafting using a recombinant human morphogenetic protein (rhBMP)-2 supplemented allograft or an autologous iliac crest bone graft (ICBG). Equivalence of rhBMP-2 to ICBG was tested for radiographic union rate, using an equivalence margin of -20% to +20%. Comparison of groups could not conclude equ...

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