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Volume:7 Issue:1 Number:21 ISSN#:2563-5476
RCT
ACE Report #10579
Ace Report Cover Arthroplasty

Increasing number of IV TXA doses further improves efficacy without increasing VTE risk in THA


Study Type:Randomized Trial
OE Level Evidence:1
Journal Level of Evidence:N/A

Multiple-Dose Intravenous Tranexamic Acid Further Reduces Hidden Blood Loss After Total Hip Arthroplasty: A Randomized Controlled Trial

J Arthroplasty. 2018 Sep;33(9):2940-2945. doi: 10.1016/j.arth.2018.04.024

Contributing Authors: F Pei Q Huang G Chen J Xie Z Huang Y Lei

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Synopsis

150 patients scheduled for total hip arthroplasty and administered an intravenous dose of tranexamic acid prior to incision were randomized to either an additional 2, 3, or 4 IV TXA doses after 3 hour intervals thereafter. Patients were assessed for hidden blood loss, total blood loss, intraoperative blood loss, hemoglobin drop, transfusion rate, length of hospital stay, and incidence of thromboem...

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