Tetrahydrocannabinol similar in efficacy & safety as placebo in improving spasticity and pain in MS

How to Cite

OrthoEvidence. Tetrahydrocannabinol similar in efficacy & safety as placebo in improving spasticity and pain in MS. ACE Report. 2018;7(10):6. Available from: https://myorthoevidene.com/AceReport/Report/10354

Study Type:Therapy

OE Level Evidence:1

Journal Level of Evidence:N/A

Effects on Spasticity and Neuropathic Pain of an Oral Formulation of delta9-Tetrahydrocannabinol in Patients With Progressive Multiple Sclerosis

Clin Ther. 2018 Sep;40(9):1467-1482. doi: 10.1016/j.clinthera.2017.01.016

Contributing Authors: G van Amerongen K Kanhai AC Baakman J Heuberger E Klaassen TL Beumer RLM Strijers J Killestein J van Gerven A Cohen GJ Groeneveld

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Synopsis

24 patients diagnosed with progressive multiple sclerosis (MS) experiencing pain and moderate spasticity were randomly assigned to either treatment with an oral formulation of Δ9-tetrahydrocannabinol (ECP002A) or placebo for 4 weeks. Improvements in symptoms were assessed by objective and subjective measures, and the incidence and nature of adverse events were monitored. The results demonstrated n...